HRID1049749

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13352409

4-Fluoro-2-methoxybenzoyl chloride

C8H6ClFO2

结构：O=C1CC(=O)N(CCNC(=O)c2ccccc2I)c2ccc3ccccc3c2N1

HCID117699125

未命名化合物

结构：Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1

HCID117699167

未命名化合物

PRODUCTS

生成物

结构：COc1cc(F)ccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1

HCID117699038

未命名化合物

收率 62%

PROCEDURE

实验过程

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione obtained in Example 1, (3), and 4-fluoro-2-methoxybenzoyl chloride, the title compound (yield 62%) was obtained in the same manner as that of Example 1, (4).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-62754f5ee39f4f57a289c81f21253dcd
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09382236B2
来源说明: uspto-grants-2016_07

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1.[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[C:28]([O:35][CH3:36])[CH:27]=1.IC1C=CC=CC=1C(NCCN1C(=O)CC(=O)NC2C3C(C=CC1=2)=CC=CC=3)=O>>[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]4[C:17]5[C:22]([CH:23]=[CH:24][C:9]3=4)=[CH:21][CH:20]=[CH:19][CH:18]=5)=[CH:4][CH:3]=2)=[O:31])=[C:28]([O:35][CH3:36])[CH:27]=1