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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1049757Generated: October 26, 2026

2-Methoxy-6-methylbenzoyl chloride → 5-[4-(2-Methoxy-6-methylbenzoylamino)phenyl]1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

https://huagongshe.com/reaction/1049757

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxy-6-methylbenzoyl chlorideHCID 12892675—
Reactant5-[2-(2-Iodobenzoyl)aminoethyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699125—
Reactant5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699167—
Product5-[4-(2-Methoxy-6-methylbenzoylamino)phenyl]1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 11769917761%

Reaction Steps

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione obtained in Example 1, (3), and 2-methoxy-6-methylbenzoyl chloride, the title compound (yield 61%) was obtained in the same manner as that of Example 1, (4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09382236B2
Source datasetuspto-grants-2016_07
ORD IDord-8272a5bf97b24564811bd4bfbc3e2c07
Source noteuspto-grants-2016_07