HRID1049764

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66648

2-Chlorobenzylamine

C7H8ClN

结构：O=C1CC(=O)N(c2ccc(C(=O)Nc3ccccc3)cc2)c2ccc3ccccc3c2N1

HCID117699098

未命名化合物

结构：O=C1CC(=O)N(c2ccc(C(=O)O)cc2)c2ccc3ccccc3c2N1

HCID117699181

未命名化合物

PRODUCTS

生成物

结构：O=C1CC(=O)N(c2ccc(C(=O)NCc3ccccc3Cl)cc2)c2ccc3ccccc3c2N1

HCID117699187

未命名化合物

收率 15%

PROCEDURE

实验过程

By using 4-[2,4-dioxo-3,4-dihydro-1H-naphtho[2,1-b][1,4]diazepin-5(2H)-yl]benzoic acid obtained in Example 102, (4), and 2-chlorobenzylamine, the title compound (yield 15%) was obtained in the same manner as that of Example 102, (5).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5262c1d25cdb4d9e8fed9023aa8f5274
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09382236B2
来源说明: uspto-grants-2016_07

反应 SMILES

[O:1]=[C:2]1[CH2:8][C:7](=[O:9])[N:6]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)[C:5]2[CH:19]=[CH:20][C:21]3[C:26]([C:4]=2[NH:3]1)=[CH:25][CH:24]=[CH:23][CH:22]=3.[Cl:27][C:28]1[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][NH2:31].C1(NC(C2C=CC(N3C(=O)CC(=O)NC4C5C(C=CC3=4)=CC=CC=5)=CC=2)=O)C=CC=CC=1>>[Cl:27][C:28]1[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][NH:31][C:14]([C:13]1[CH:12]=[CH:11][C:10]([N:6]2[C:7](=[O:9])[CH2:8][C:2](=[O:1])[NH:3][C:4]3[C:26]4[C:21]([CH:20]=[CH:19][C:5]2=3)=[CH:22][CH:23]=[CH:24][CH:25]=4)=[CH:18][CH:17]=1)=[O:16]