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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1049771Generated: November 1, 2026

2-Methoxy-6-(trifluoromethyl)benzoyl chloride → 5-[4-[2-Methoxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

https://huagongshe.com/reaction/1049771

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxy-6-(trifluoromethyl)benzoyl chlorideHCID 15017534—
Reactant5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699167—
Reactant4-[2,4-Dioxo-3,4-dihydro-1H-naphtho[2,1-b][1,4]diazepin-5(2H)-yl]benzoic acidHCID 117699181—
Product5-[4-[2-Methoxy-6-(trifluoromethyl)benzoylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 11769916274%

Reaction Steps

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione obtained in Example 1, (3), and 2-methoxy-6-(trifluoromethyl)benzoyl chloride, the title compound (yield 74%) was obtained in the same manner as that of Example 1, (4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09382236B2
Source datasetuspto-grants-2016_07
ORD IDord-b1826b39fd6f4c6e8900e8e4225c23f7
Source noteuspto-grants-2016_07