2-Methylbenzenecarbothioyl chloride → HCID 117699051, compound

HRID 1049772Notes

Reaction equation

HRID 1049772 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1.CC1C=CC=CC=1[C:28](Cl)=[S:29].O=C1CC(=O)N([C:44]2[CH:52]=[CH:51][C:47]([C:48](O)=[O:49])=[CH:46][CH:45]=2)C2C=CC3C(C=2N1)=CC=CC=3>>[CH3:28][S:29][C:51]1[CH:52]=[CH:44][CH:45]=[CH:46][C:47]=1[C:48]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1)=[O:49]

Participants

4

Reactant 3

HCID 128493892-Methylbenzenecarbothioyl chlorideHCID 1176991675-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 1176991814-[2,4-Dioxo-3,4-dihydro-1H-naphtho[2,1-b][1,4]diazepin-5(2H)-yl]benzoic acid

Product 1

HCID 117699051HCID 117699051, compoundYield 20%

Procedure

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (30 mg, 0.095 mmol) obtained in Example 1, (3), and 2-methylthiobenzoyl chloride (0.24 mmol), the title compound (22 mg, yield 20%) was obtained in the same manner as that of Example 1, (4).

Sources & evidence

ORD record
ord-471caa175c4b4c24a1cc03e270e634ea
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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