HCID 117699023, compound → HCID 117699451, compound

HRID 1049774Notes

Reaction equation

HRID 1049774 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1.[CH2:25]([C:27]1[CH:35]=[CH:34][C:33](OC)=[CH:32][C:28]=1[C:29](Cl)=[O:30])[CH3:26].[O:38]=[C:39]1CC(=O)N(C2C=CC(C(O)=O)=CC=2)C2C=CC3C(C=2N1)=CC=CC=3>>[CH2:25]([C:27]1[CH:35]=[CH:34][CH:33]=[C:32]([O:38][CH3:39])[C:28]=1[C:29]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1)=[O:30])[CH3:26]

Participants

4

Reactant 3

HCID 117699023HCID 117699023, compoundHCID 1176991675-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 1176991814-[2,4-Dioxo-3,4-dihydro-1H-naphtho[2,1-b][1,4]diazepin-5(2H)-yl]benzoic acid

Product 1

HCID 117699451HCID 117699451, compoundYield 90%

Procedure

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (50 mg, 0.16 mmol) obtained in Example 1, (3), and 2-ethyl-5-methoxybenzoyl chloride (0.24 mmol), the title compound (69 mg, yield 90%) was obtained in the same manner as that of Example 1, (4).

Sources & evidence

ORD record
ord-3a8af5a6185d407096bb7c07a71fdf6c
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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