2-Iodobenzoyl chloride → 6-Ethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

HRID 1049775Notes

Reaction equation

HRID 1049775 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]([CH2:21][CH3:22])=[CH:18][CH:19]=[CH:20][C:9]2=3)=[CH:4][CH:3]=1.[I:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26](Cl)=[O:27]>>[CH2:21]([C:17]1[C:10]2[NH:11][C:12](=[O:16])[CH2:13][C:14](=[O:15])[N:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:26](=[O:27])[C:25]4[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=4[I:23])=[CH:7][CH:6]=3)[C:9]=2[CH:20]=[CH:19][CH:18]=1)[CH3:22].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]([CH2:21][CH3:22])=[CH:18][CH:19]=[CH:20][C:9]2=3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 691122-Iodobenzoyl chlorideHCID 1176991231-(4-Aminophenyl)-6-ethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

Product 2

HCID 1176990726-Ethyl-1-[4-(2-iodobenzoyl)aminophenyl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dioneHCID 1176991231-(4-Aminophenyl)-6-ethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

Procedure

By using 1-(4-aminophenyl)-6-ethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione, and 2-iodobenzoyl chloride, the title compound was obtained in the same manner as that of Example 1, (4).

Sources & evidence

ORD record
ord-0a55eda004b74b2d939eaebe7b62b22f
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

Loading…