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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1049779Generated: October 31, 2026

3-Chloro-2-methoxybenzoic acid chloride → 5-[4-(3-Chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

https://huagongshe.com/reaction/1049779

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-2-methoxybenzoic acid chlorideHCID 17803474—
Reactant1-(4-Aminophenyl)-6-ethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699123—
Reactant5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699167—
Product5-[4-(3-Chloro-2-methoxybenzoylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 1176994409%

Reaction Steps

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione obtained in Example 1, (3), and 3-chloro-2-methoxybenzoyl chloride, the title compound (yield 9%) was obtained in the same manner as that of Example 1, (4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09382236B2
Source datasetuspto-grants-2016_07
ORD IDord-652eeb58053b43019b79dce2a29d6ac4
Source noteuspto-grants-2016_07