Benzenesulfonyl chloride → HCID 117699099, compound

HRID 1049789Notes

Reaction equation

HRID 1049789 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:10]=3[NH:11][C:12](=[O:15])[CH2:13][N:14]=2)[CH:5]=[CH:6][CH:7]=1.[C:24]1([S:30](Cl)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>N1C=CC=CC=1>[O:15]=[C:12]1[NH:11][C:10]2[C:16]3[C:21]([CH:22]=[CH:23][C:9]=2[C:8]([C:4]2[CH:3]=[C:2]([NH:1][S:30]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)(=[O:32])=[O:31])[CH:7]=[CH:6][CH:5]=2)=[N:14][CH2:13]1)=[CH:20][CH:19]=[CH:18][CH:17]=3

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 117699283HCID 117699283, compound

Product 1

HCID 117699099HCID 117699099, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

5-(3-Aminophenyl)-1,3-dihydronaphtho[1,2-e]-1,4-diazepin-2-one (10 mg, 0.033 mmol), and benzenesulfonyl chloride (13 μL, 0.1 mmol) were treated by heating in pyridine (1.0 mL). A post-treatment was performed in a conventional manner to give the title compound (14 mg, yield 95%) as white amorphous.

Sources & evidence

ORD record
ord-a004f6181f134176bc4604a48918031d
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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