(2-Chlorophenyl)methanesulfonyl chloride → HCID 117699033, compound

HRID 1049819Notes

Reaction equation

HRID 1049819 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[C:18]([CH3:19])[C:13]=3[NH:12][C:11](=[O:20])[CH2:10][C:9]2=[O:21])=[CH:4][CH:3]=1.[Cl:22][C:23]1[CH:33]=[CH:32][CH:31]=[CH:30][C:24]=1[CH2:25][S:26](Cl)(=[O:28])=[O:27]>>[Cl:22][C:23]1[CH:33]=[CH:32][CH:31]=[CH:30][C:24]=1[CH2:25][S:26]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:9](=[O:21])[CH2:10][C:11](=[O:20])[NH:12][C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]2=3)=[CH:4][CH:3]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 2757801(2-Chlorophenyl)methanesulfonyl chlorideHCID 117699136HCID 117699136, compound

Product 1

HCID 117699033HCID 117699033, compoundYield 96%

Procedure

By using 1-(4-aminophenyl)-6-methyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (20 mg, 0.071 mmol), and 2-chlorobenzylsulfonyl chloride (19 mg, 0.084 mmol), the title compound (32 mg, yield 96%) was obtained in the same manner as that of Example 145.

Sources & evidence

ORD record
ord-cf011916e9134b02b28fca74d725d267
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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