HCID 22444188, compound → HCID 117699270, compound

HRID 1049823Notes

Reaction equation

HRID 1049823 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:15](=[O:16])[CH2:14][C:13](=[O:17])[NH:12][C:11]3[C:18]4[C:23]([CH:24]=[CH:25][C:10]2=3)=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:5][CH:4]=1.C([C:28]1[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=1[CH2:30][S:31](Cl)(=[O:33])=[O:32])C>N1C=CC=CC=1>[CH2:19]([C:18]1[CH:23]=[CH:24][CH:25]=[CH:10][C:11]=1[C:29]1([CH2:30][S:31]([N:2]([C:3]2[CH:4]=[CH:5][C:6]([N:9]3[C:15](=[O:16])[CH2:14][C:13](=[O:17])[NH:12][C:11]4[C:18]5[C:23]([CH:24]=[CH:25][C:10]3=4)=[CH:22][CH:21]=[CH:20][CH:19]=5)=[CH:7][CH:8]=2)[CH3:1])(=[O:32])=[O:33])[CH:28]=[CH:38][CH:37]=[CH:36][CH2:35]1)[CH3:20]

Participants

4

Reactant 2

HCID 22444188HCID 22444188, compoundHCID 117699077HCID 117699077, compound

Product 1

HCID 117699270HCID 117699270, compoundYield 27.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

5-[4-(Methylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (40 mg, 0.121 mmol) obtained in Example 198, (1), and 2-ethylbenzylsulfonyl chloride (132 mg, 0.605 mmol) were treated by heating in pyridine (1.0 mL). After the disappearance of the starting materials was confirmed, the same treatment as that of Example 145 was performed to obtain the title compound (10 mg, yield 16%) as white crystals.

Sources & evidence

ORD record
ord-7338149f841d4a5c97a1fb86f6c966f8
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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