1215922-05-6 → HCID 117720126, compound

HRID 1049824Notes

Reaction equation

HRID 1049824 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:15](=[O:16])[CH2:14][C:13](=[O:17])[NH:12][C:11]3[C:18]4[C:23]([CH:24]=[CH:25][C:10]2=3)=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:5][CH:4]=1.C[C:27]1[C:37](C)=[CH:36][CH:35]=[CH:34][C:28]=1[CH2:29][S:30](Cl)(=[O:32])=[O:31]>N1C=CC=CC=1>[CH3:19][C:18]1[C:23]([CH3:22])=[CH:24][CH:25]=[CH:10][C:11]=1[C:28]1([CH2:29][S:30]([N:2]([C:3]2[CH:4]=[CH:5][C:6]([N:9]3[C:15](=[O:16])[CH2:14][C:13](=[O:17])[NH:12][C:11]4[C:18]5[C:23]([CH:24]=[CH:25][C:10]3=4)=[CH:22][CH:21]=[CH:20][CH:19]=5)=[CH:7][CH:8]=2)[CH3:1])(=[O:31])=[O:32])[CH:27]=[CH:37][CH:36]=[CH:35][CH2:34]1

Participants

4

Reactant 2

HCID 620847231215922-05-6HCID 117699077HCID 117699077, compound

Product 1

HCID 117720126HCID 117720126, compoundYield 55.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

5-[4-(Methylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (40 mg, 0.121 mmol) obtained in Example 198, (1), and 2,3-dimethylbenzylsulfonyl chloride (132 mg, 0.605 mmol) were treated by heating in pyridine (1.0 mL). After the disappearance of the starting materials was confirmed, the same treatment as that of Example 145 was performed to give the title compound (20 mg, yield 32%) as pale yellow crystals.

Sources & evidence

ORD record
ord-fc69083ad2c74c8e85f2ba9b7ca4e0d1
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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