tert-Butyl (4-aminophenyl)carbamate → HCID 131736046, compound

HRID 1049833Notes

Reaction equation

HRID 1049833 reaction equation
FC(F)(F)S(O[C:7]1[C:8]([N+:17]([O-:19])=[O:18])=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[N:12][CH:11]=[CH:10]2)(=O)=O.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:25][CH:24]=1>>[C:32]([O:31][C:30](=[O:36])[NH:29][C:26]1[CH:25]=[CH:24][C:23]([NH:22][C:7]2[C:8]([N+:17]([O-:19])=[O:18])=[C:9]3[C:14](=[CH:15][CH:16]=2)[CH:13]=[N:12][CH:11]=[CH:10]3)=[CH:28][CH:27]=1)([CH3:35])([CH3:33])[CH3:34]

Participants

3

Reactant 2

HCID 688611tert-Butyl (4-aminophenyl)carbamateHCID 117699235HCID 117699235, compound2×

Product 1

HCID 131736046HCID 131736046, compoundYield 26.3%

Procedure

By using 5-nitroisoquinolin-6-yl trifluoromethanesulfonate (258 mg, 0.8 mmol), and tert-butyl 4-aminophenylcarbamate (250 mg, 1.2 mmol), the title compound (80 mg, yield 26%) was obtained as red crystals in the same manner as that of Example 1, (1).

Sources & evidence

ORD record
ord-9d92bc3d20db4e54a3191a74b10b497c
Source dataset
uspto-grants-2016_07
Patent number
US09382236B2

Reaction notes

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