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Hydrochloric Acid → HCID 73442130、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2(3H)-Benzothiazolone, 6-amino- | HCID 6453329 | — |
| 反応物 | HCID 90079428 | HCID 90079428 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | HCID 73442130 | HCID 73442130 | 85.4% |
反応手順
A mixture comprising 60.0 mg (307 μmol) 4-chloro-6-ethyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to intermediate example 1a), 51 mg 6-amino-1,3-benzothiazol-2(3H)-one (CAS-No: 56354-98-4), 1.75 mL ethanol and 16.9 μL hydrochloric acid (4M in dioxane) was reacted at 110° C. for 10 hours. The residue was digested in a mixture of diethyl ether and ethanol and dried to give 85.3 mg (85%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09382255B2 |
| 出典データセット | uspto-grants-2016_07 |
| ORD ID | ord-dfea4ded87f34c32831e5a0502fc0fdd |
| 出典メモ | uspto-grants-2016_07 |