Phosphorus oxychloride → 4-Chloro-6-ethyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

関与物質

反応手順

A mixture comprising 1.18 g (6.64 mmol) 6-ethyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol (prepared according to intermediate example 1b) and 37.1 mL phosphorus oxychloride was heated at 100° C. for 1 hour. The reagent was removed and the residue purified by chromatography. The product was further purified by digestion with diethyl ether to give 855 mg (66%) of the title compound.

情報源と証拠