Sodium Hydroxide → HCID 73442183, compound

Participants

Reaction Steps

A mixture comprising 18.7 mg (57 μmol) 4-[(2-Oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid (prepared according to example 3), 0.64 mL N,N-dimethylformamide, 57.2 mg 1-methylpiperazine, 136 μL 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide solution (50% in ethyl acetate) and 29.9 μL N-ethyl-N-isopropylpropan-2-amine was stirred at 23° C. for 2 days. Water was added, the solution was neutralized by addition of sodium hydroxide solution, the solvents were removed and the residue purified by chromatography to give 10.9 mg (44%) of the title compound.

Provenance & Evidence