Ethanol → HCID 73442248, compound

Participants

Reaction Steps

A mixture comprising 262 mg (777 μmol) 6-{[6-(3-hydroxyprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 11), 15 mL ethanol, 5 mL tetrahydrofuran and 41.3 mg palladium on charcoal (10%) were stirred at 23° C. under an atmosphere of hydrogen overnight. After filtration and removal of the solvents the crude product was purified by chromatography and crystallization to give 12 mg (4%) of the title compound.

Provenance & Evidence