6-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidine → HCID 73442249, compound

HRID 1049845Notes

Reaction equation

HRID 1049845 reaction equation
[Br:1][C:2]1[NH:11][C:5]2[N:6]=[CH:7][N:8]=[C:9](Cl)[C:4]=2[CH:3]=1.[NH2:12][C:13]1[C:22]([O:23][CH3:24])=[CH:21][C:16]2[NH:17][C:18](=[O:20])[S:19][C:15]=2[CH:14]=1>>[Br:1][C:2]1[NH:11][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:12][C:13]3[C:22]([O:23][CH3:24])=[CH:21][C:16]4[NH:17][C:18](=[O:20])[S:19][C:15]=4[CH:14]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 457898276-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidineHCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-one

Product 1

HCID 73442249HCID 73442249, compound

Procedure

25 mg (108 μmol) 6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS-No: 784150-41-0) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 11.8 mg (27%) of the title compound.

Workup

  1. customto give
  2. custompurification 11.8 mg (27%) of the title compound

Sources & evidence

ORD record
ord-4e3a39a4397c4fb3991c1f10776a9933
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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