7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → HCID 73442250, compound

HRID 1049846Notes

Reaction equation

HRID 1049846 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:11][C:12]1[C:21]([O:22][CH3:23])=[CH:20][C:15]2[NH:16][C:17](=[O:19])[S:18][C:14]=2[CH:13]=1>>[CH3:23][O:22][C:21]1[C:12]([NH:11][C:2]2[C:3]3[CH:10]=[CH:9][NH:8][C:4]=3[N:5]=[CH:6][N:7]=2)=[CH:13][C:14]2[S:18][C:17](=[O:19])[NH:16][C:15]=2[CH:20]=1

Participants

3

Reactant 2

HCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-one

Product 1

HCID 73442250HCID 73442250, compound

Procedure

20 mg (130 μmol) 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS-No. 3680-59-1) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 8.0 mg (19%) of the title compound.

Workup

  1. customto give
  2. custompurification 8.0 mg (19%) of the title compound

Sources & evidence

ORD record
ord-c22f0aa9f6e04507a94e26cb28fc2cc9
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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