Dimethylamine → HCID 73442303, compound

HRID 1049847Notes

Reaction equation

HRID 1049847 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12]3[C:13]4[C:20]([C:21](O)=[O:22])=[CH:19][NH:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:10][C:4]=2[S:3]1.[CH3:24][NH:25][CH3:26]>>[CH3:24][N:25]([CH3:26])[C:21]([C:20]1[C:13]2[C:12]([NH:11][C:9]3[CH:8]=[CH:7][C:5]4[NH:6][C:2](=[O:1])[S:3][C:4]=4[CH:10]=3)=[N:17][CH:16]=[N:15][C:14]=2[NH:18][CH:19]=1)=[O:22]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 73442132HCID 73442132, compound

Product 1

HCID 73442303HCID 73442303, compound

Procedure

64.6 mg (178 μmol) 4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid (prepared according to example 3) were transformed in analogy to example 4 using N-methylmethanamine to give after working up and purification 32.6 mg (49%) of the title compound.

Workup

  1. customto give
  2. custompurification 32.6 mg (49%) of the title compound

Sources & evidence

ORD record
ord-e8407ee8d38749b79209da89a228e1d1
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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