Hydrochloric Acid → 4-[(5-Methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

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Reaction Steps

A mixture of 15 mg (39 μmol) ethyl 4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (prepared according to example 25), 234 μL aqueous lithium hydroxide (1 molar), and 1.0 mL tetrahydrofuran was stirred at room temperature overnight. The mixture was then acidified by addition of aqueous hydrochloric acid (4 N). The precipitate was filtered, washed with water and diethyl ether and dried to give 10.1 mg (69%) of the title compound.

Provenance & Evidence