6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one → HCID 73442366, compound

HRID 1049855Notes

Reaction equation

HRID 1049855 reaction equation
Cl[C:2]1[C:3]2[C:10]([CH2:11][CH3:12])=[C:9]([CH2:13][CH2:14][CH3:15])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:16][C:17]1[C:26]([O:27][CH3:28])=[CH:25][C:20]2[NH:21][C:22](=[O:24])[S:23][C:19]=2[CH:18]=1>>[CH2:11]([C:10]1[C:3]2[C:2]([NH:16][C:17]3[C:26]([O:27][CH3:28])=[CH:25][C:20]4[NH:21][C:22](=[O:24])[S:23][C:19]=4[CH:18]=3)=[N:7][CH:6]=[N:5][C:4]=2[NH:8][C:9]=1[CH2:13][CH2:14][CH3:15])[CH3:12]

Participants

3

Reactant 2

HCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-oneHCID 90079401HCID 90079401, compound

Product 1

HCID 73442366HCID 73442366, compound

Procedure

100 mg (447 μmol) 4-chloro-5-ethyl-6-propyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to intermediate example 22a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 3.2 mg (2%) of the title compound.

Workup

  1. customto give
  2. custompurification 3.2 mg (2%) of the title compound

Sources & evidence

ORD record
ord-fcca9a5ec27a4d35b9cfdd688c57437f
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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