Morpholine → HCID 73442369, compound

HRID 1049857Notes

Reaction equation

HRID 1049857 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12]3[C:13]4[CH:20]=[C:19]([C:21]([OH:23])=O)[NH:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:10][C:4]=2[S:3]1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:24]1([C:21]([C:19]2[NH:18][C:14]3[N:15]=[CH:16][N:17]=[C:12]([NH:11][C:9]4[CH:8]=[CH:7][C:5]5[NH:6][C:2](=[O:1])[S:3][C:4]=5[CH:10]=4)[C:13]=3[CH:20]=2)=[O:23])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 73442367HCID 73442367, compound

Product 1

HCID 73442369HCID 73442369, compound

Procedure

150 mg (458 μmol) 4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (prepared according to example 30) were transformed in analogy to example 4 using morpholine to give after working up and purification 25.0 mg (12%) of the title compound.

Workup

  1. customto give
  2. custompurification 25.0 mg (12%) of the title compound

Sources & evidence

ORD record
ord-2502751193d94f6a80c683f2ac9ae7e6
Source dataset
uspto-grants-2016_07
Patent number
US09382255B2

Reaction notes

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