Acetyl chloride → HCID 6852048, compound

HRID 1049859Notes

Reaction equation

HRID 1049859 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[C:10](Cl)(=[O:12])[CH3:11]>N1C=CC=CC=1.O>[C:10]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])(=[O:12])[CH3:11]

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 6994952-Aminothiophene-3-carboxamide

Product 1

HCID 6852048HCID 6852048, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

A solution of 2-Amino-thiophene-3-carboxylic acid amide (20.3 g, 143 mmol) in dry pyridine (150 mL) is cooled to 0° C. Acetylchloride (11 mL, 156 mmol) is added dropwise to the solution. The resulting mixture was stirred at room temperature overnight. The mixture is then diluted with water and the resulting suspension is filtered. The cake is dried overnight in a vacuum-oven at 50° C. to yield the desired product.

Workup

  1. filtrationthe resulting suspension is filtered
  2. customThe cake is dried overnight in a vacuum-oven at 50° C.

Sources & evidence

ORD record
ord-6b87e25a20c14ff0a2d4b2332aad0b0c
Source dataset
uspto-grants-2016_07
Patent number
US09382254B2

Reaction notes

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