反应详情

A solution of 2-amino-4-methyl-thiophene-3-carboxylic acid amide (5 g, 32 mmol) in DCM (100 mL) is cooled to 0° C. Dry pyridine (3.6 mL, 45 mmol) is added, followed by acetylchloride (11 mL, 156 mmol) which is added dropwise to the solution. The resulting mixture is stirred at room temperature overnight, then diluted with DCM and washed with aqueous NaHCO3. The organic phase is dried over MgSO4, filtered and concentrated. The obtained residue is triturated in di-isopropylether, filtered, and the cake is dried to afford the desired product.

1. additionis added dropwise to the solution
2. washwashed with aqueous NaHCO3
3. dry with materialThe organic phase is dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe obtained residue is triturated in di-isopropylether
7. filtrationfiltered
8. customthe cake is dried