Chlorosulfonic acid → 5-Acetylamino-4-carbamoyl-3-methyl-thiophene-2-sulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

Neat ClSO3H (6.7 mL, 100 mmol) is cooled to 0° C. 2-acetylamino-4-methyl-thiophene-3-carboxylic acid amide (1.98 g, 10 mmol) is added in portions over a period of 15 min, and the mixture is stirred at 40° C. for 3 h. The mixture is cooled down to room temperature and poured slowly onto ice cold water. The resulting suspension is washed twice with EtOAc, the combined organic fractions are dried over MgSO4, filtered and evaporated to yield the desired product which is used as such.

Provenance & Evidence