2-Fluorobenzoic acid → HCID 117704012, compound

Participants

Reaction Steps

A solution of 2-Amino-5-(4,4-difluoro-piperidine-1-sulfonyl)-thiophene-3-carboxylic acid amide (53 mg, 0.18 mmol), TEA (125 μL, 0.90 mmol), DMAP (7 mg, 0.054 mmol), 2-Chloro-1-methylpyridinium iodide (60 mg, 0.23 mmol) and 2-fluorobenzoic acid (33 mg, 0.23 mmol) in DCM is stirred at 80° C. overnight. The mixture is then diluted with DCM and washed with aqueous NaHCO3. The organic phase is isolated evaporated, and the residue is purified by preparative chromatography to yield the desired product.

Provenance & Evidence