Pyridine → HCID 178513700, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1H-Pyrazole-3-carbonyl chloride (5 mmol) in MeCN (5 mL) is added dropwise to a solution of 2-amino-thiophene-3-carboxylic acid amide (570 mg, 4 mmol), pyridine (0.5 mL, 6 mmol) and DMAP (25 mg, 0.20 mmol) in MeCN (5 mL). The resulting solution is than stirred at 60° C. over 2 days. The mixture is then quenched with aqueous NaHCO3, concentrated under vacuo to afford a suspension that is filtered. The cake is dried and the solid is used as such.

Provenance & Evidence