N-Iodosuccinimide → HCID 90104537, compound

Participants

Reaction Steps

To a solution of 28 (0.27 g) and acetone (20 mL) was added in one portion NIS (0.36 g). The mixture was stirred at RT for 30 min and then concentrated to afford 0.55 g of crude material which was purified by SiO2 chromatography using an EtOH/EtOAc gradient (1 to 15% EtOH over 15 min) to afford 0.29 g of pure 7-iodo-2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine (30).

Provenance & Evidence