反应详情

To a solution of 3-bromo-5-fluoroaniline (CAS 134168-97-1) (3.0 g, 16 mmol) in EtOH (50 mL), was added HOAc (900 mg, 16 mmol), and oxetan-3-one (CAS 6704-31-0) (2.4 g, 32 mmol). The mixture was stirred at reflux for overnight. It was poured into water (100 mL) and extract with EtOAc (100 mL×2). The combined organic layers was dried over Na2SO4 and concentrated in vacuum to give the crude product (3.0 g, 77%).

1. temperatureat reflux for overnight
2. extractionextract with EtOAc (100 mL×2)
3. dry with materialThe combined organic layers was dried over Na2SO4
4. concentrationconcentrated in vacuum