HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → 2-(3-Bromophenoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromophenol | HCID 11563 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-Bromophenoxy)pyridine | HCID 21616612 | 30.3% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A suspension of 2-bromopyridine (commercially available) (2.0 g, 13.6 mmol), 3-bromophenol (CAS591-20-8) (4.4 g, 24.9 mmol), K2CO3 (5.2 g, 40 mmol) in DMF (30 mL) was stirred at 130° C. for 30 h. The mixture was filtered, concentrated, and purified by column chromatography to give titled compound (1.0 g, 30.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382241B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-430fde663951413fbf7a618407a6c87e |
| Source note | uspto-grants-2016_07 |