Sodium Cyanide → 2-(4-Bromo-2-fluorophenyl)acetonitrile

Participants

Reaction Conditions

Reaction Steps

To a suspension of NaCN (2.085 g, 42.5 mmol) in DMF (20 mL) was added to a solution of 4-bromo-1-(bromomethyl)-2-fluorobenzene (5.7 g, 21.27 mmol) in DMF (20 mL). The mixture was stirred at 26° C. for 10 h. Then the solution was concentrated and partioned between EA (50 mL) and saturated NaHCO3 solution (50 mL). The organic extract was washed with brine (50 mL), dried over MgSO4, filtered and concentrated to give a off white solid of 2-(4-bromo-2-fluorophenyl)acetonitrile (4.01 g, 18.74 mmol, 88% yield): 1H NMR (400 MHz, CDCl3) δ 7.24-7.37 (m, 3H), 3.70 (s, 2H).

Provenance & Evidence