HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1050185Generated: October 31, 2026
Ethyl Acetate → 3-Nitro-5-(trifluoromethyl)benzoyl chloride
https://huagongshe.com/reaction/1050185
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Nitro-5-(trifluoromethyl)benzoic acid | HCID 616602 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Nitro-5-(trifluoromethyl)benzoyl chloride | HCID 22608399 | 76.4% |
Reaction Steps
A mixture of 3-nitro-5-(trifluoromethyl)benzoic acid (2 g, 8.51 mmol) in DCM (30 mL) was added SOCl2 (1.242 mL, 17.01 mmol) at 20° C. The mixture was stirred at 20° C. for 2 h. TLC (PE/EA=2:1, Rf=0.3) showed the reaction was finished. The mixture was concentrated to give 3-nitro-5-(trifluoromethyl)benzoyl chloride (1.8 g, 6.50 mmol, 76% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09382238B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-a99d5b23d3594fa1bdad00389bc00959 |
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| Source note | uspto-grants-2016_07 |
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