HCID 118519575, compound → HCID 118519578, compound

HRID 1050208Notes

Reaction equation

HRID 1050208 reaction equation
[O:1]=[C:2]1[N:6]2[C:7]3[CH:14]=[CH:13][C:12]([N:15]4[CH:19]=[CH:18][O:17][C:16]4=[O:20])=[CH:11][C:8]=3[O:9][CH2:10][C@H:5]2[C@H:4]([CH2:21][N:22]2C(=O)C3C(=CC=CC=3)C2=O)[O:3]1>C(O)C>[NH2:22][CH2:21][C@H:4]1[C@H:5]2[N:6]([C:7]3[CH:14]=[CH:13][C:12]([N:15]4[CH:19]=[CH:18][O:17][C:16]4=[O:20])=[CH:11][C:8]=3[O:9][CH2:10]2)[C:2](=[O:1])[O:3]1

Participants

3

Reactant 1

HCID 118519575HCID 118519575, compound

Product 1

HCID 118519578HCID 118519578, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using compound 2-(((3S,3aS)-1-oxo-7-(2-oxooxazol-3-yl)-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methyl)isoindolin-1,3-dione (0.26 g, 0.586 mmol), and methylamine alcohol (0.15 g, 4.686 mmol) as starting materials, ethanol as solvent, preparation following the method as described in Example 1(e) afforded a crude product, which was directly subjected to the next step of reaction without purification.

Workup

  1. custompreparation

Sources & evidence

ORD record
ord-a881b302d36c4c51a66bead4d4515923
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

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