HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 118519582, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118519578 | HCID 118519578 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118519582 | HCID 118519582 | 76.9% |
Reaction Steps
Using compound (3S,3aS)-3-(aminomethyl)-7-(2-oxooxazol-3-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one, 5-chlorothiophene-2-carboxylic acid (0.12 g, 0.737 mmol), HATU (0.38 g, 0.982 mmol), and Et3N (0.15 g, 1.473 mmol) as starting materials, DCM (10 ml) and DMF (2 ml) as a mixed solvent, preparation following the method as described in Example 11 (g) afforded white solid 0.17 g, yield 76.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382265B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-d81da14f575d417880ec9e4498abd1fd |
| Source note | uspto-grants-2016_07 |