HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(2-chloroethyl)sulfanyl]acetic acid → HCID 118519612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(2-chloroethyl)sulfanyl]acetic acid | HCID 230247 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 90295505 | HCID 90295505 | — |
| Product | HCID 118519612 | HCID 118519612 | 61.3% |
Reaction Steps
Using compound 2-((2-chloroethyl)thio) acetic acid (58 mg, 0.377 mmol), compound (3S,3aS)-3-aminomethyl-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one (the product of step (e) in Example 1) (80 mg, 0.251 mmol), TEA (76.2 mg, 0.753 mmol), and HATU (171 mg, 0.452 mmol) as starting materials, preparation following the method as described in Example 11 (g) afforded white solid 70 mg, yield 61.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382265B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-2f5ed4ca873249018ffbbf40424b320c |
| Source note | uspto-grants-2016_07 |