HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-picolinic acid → HCID 131736052, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-picolinic acid | HCID 2762872 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 90295505 | HCID 90295505 | — |
| Product | HCID 131736052 | HCID 131736052 | 85.85% |
Reaction Steps
Using compound (3S,3 aS)-3-aminomethyl-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1 (3H)-one (60 mg, 0.188 mmol) (the product of step (e) in Example 1), 5-chloropyridin-2-carboxylic acid (36 mg, 0.225 mmol), HATU (107 mg, 0.282 mmol), and TEA (38 mg, 0.376 mmol) as starting materials, preparation following the method as described in Example 11 (g) afforded white solid compound 74 mg, yield: 85.85%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382265B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-e10ebf703b52470491fbcabe64ee0959 |
| Source note | uspto-grants-2016_07 |