HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzoic Acid → HCID 118519596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzoic Acid | HCID 6318 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 90295505 | HCID 90295505 | — |
| Product | HCID 118519596 | HCID 118519596 | 83.68% |
Reaction Steps
Using compound (3S,3aS)-3-aminomethyl-7-(3-oxomorpholin-4-yl)-3a,4-dihydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-1(3H)-one (the product of step (e) in Example 1) (60 mg, 0.188 mmol), p-chlorobenzoic acid (35 mg, 0.225 mmol), HATU (107 mg, 0.282 mmol), and TEA (38 mg, 0.376 mmol) as starting materials, preparation following the method as described in Example 11 (g) afforded white solid compound 72 mg, yield: 83.68%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382265B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-8ceba7dffe73407ca7c6f9a471e06ce5 |
| Source note | uspto-grants-2016_07 |