HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-2-piperidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | 4-hydroxy-2-Piperidinone | HCID 11251988 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-2-piperidinone | HCID 90295657 | 60% |
Reaction Steps
(±) 4-hydroxypiperidin-2-one (0.80 g, 6.94 mmol) was dissolved in DMF. DMAP (0.085 g, 0.694 mmol) and imidazole (0.92 g, 13.88 mmol) were added. After the resulting mixture was stirred evenly, the solution of TBDPS-Cl (2.3 g, 8.33 mmol) in THF was added and stirred at room temperature overnight. After the reaction completed, the reaction mixture was dried by spinning. Column chromatography afforded colorless oily liquid 0.65 g, yield 60%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382265B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-d140cbacf8944a11b2015180f32266f6 |
| Source note | uspto-grants-2016_07 |