Tetrabutylammonium Fluoride → HCID 90295621, compound

Participants

Reaction Steps

Compound N-(((3S,3aS)-7-((R)-4-(t-butyldiphenylsiloxy)-2-oxopiperidin-1-yl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methyl)-5-chlorothiophene-2-carboxamide (0.36 g, 0.502 mmol) was dissolved in THF. TBAF (1M/L, 0.50 ml) was added and stirred at room temperature for 2 h. After the reaction completed, the resulting mixture was washed with water, extracted with EA (20 ml×4), dried over anhydrous sodium sulfate, and dried by spinning. Column chromatography afforded white solid 0.13 g, yield 56.2%.

Provenance & Evidence