Tetrabutylammonium Fluoride → HCID 90295494, compound

HRID 1050227Notes

Reaction equation

[O:1]([CH2:9][C@H:10]1[C@H:18]2[N:13]([C:14]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][C:15]=3[O:16][CH2:17]2)[C:12](=[O:25])[O:11]1)[Si](C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[OH:1][CH2:9][C@H:10]1[C@H:18]2[N:13]([C:14]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][C:15]=3[O:16][CH2:17]2)[C:12](=[O:25])[O:11]1

Participants

Reactant 2

HCID 2724141Tetrabutylammonium Fluoride

HCID 90295492HCID 90295492, compound

Product 1

HCID 90295494HCID 90295494, compoundYield 65.3%

Procedure

Using compound (3R,3 aS)-3-((t-butyldimethylsiloxy)methyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-carbonitrile (0.538 g, 1.494 mmol), tetra-n-butylammonium fluoride (1M, 2.99 ml) as starting materials, preparation following the method as described in Example 1(b) afforded 0.24 g white solid, yield 65.3%.

Workup

custommaterials, preparation

Sources & evidence

ORD record: ord-2e052aa8410d49afa66735c1e846e3ea
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09382265B2

Reaction notes

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