Phthalimide potassium salt → HCID 90295498, compound

HRID 1050228Notes

Reaction equation

HRID 1050228 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[N:11]3[C:12](=[O:21])[O:13][C@H:14]([CH2:15]CS([O-])(=O)=O)[C@@H:10]3[CH2:9][O:8][C:7]=2[CH:22]=1)#[N:2].[K].[C:24]1(=[O:34])[NH:28][C:27](=[O:29])[C:26]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:25]12>>[O:29]=[C:27]1[C:26]2[C:25](=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:24](=[O:34])[N:28]1[CH2:15][C@H:14]1[C@H:10]2[N:11]([C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:22][C:7]=3[O:8][CH2:9]2)[C:12](=[O:21])[O:13]1

Participants

3

Reactant 2

HCID 24194345Phthalimide potassium saltHCID 131736054HCID 131736054, compound

Product 1

HCID 90295498HCID 90295498, compoundYield 79.71%

Procedure

Using compound ((3R,3aS)-7-cyano-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methylmethanesulfonate (0.31 g, 0.957 mmol) and phthalimide potassium (0.266 g, 1.435 mmol) as starting materials, preparation following the method as described in Example 1(d) afforded white solid 0.286 g, yield: 79.71%.

Workup

  1. custommaterials, preparation

Sources & evidence

ORD record
ord-fc68227b04494eb1b16d0cf83dab19c5
Source dataset
uspto-grants-2016_07
Patent number
US09382265B2

Reaction notes

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