反应详情

5.0 g of 16α,17α-epoxy-3-methoxy-estra-1,3,5(10)-triene, 20 g sodium azide, 100 ml abs. DMSO and 30 ml glacial acetic acid are stirred at 110° C. 7 h under argon atmosphere. The mixture is then poured into water, extracted with ether, washed with 1N NaOH and then with water. After drying and removal of the solvent by distillation, the residue is chromatographed with benzene on 50 g aluminum oxide (neutral, activity level 1). Recrystallization from methanol/water yields 4.2 g (73%) of the azide.

1. custom7 h
2. extractionextracted with ether
3. washwashed with 1N NaOH
4. customAfter drying
5. customremoval of the solvent
6. distillationby distillation
7. customthe residue is chromatographed with benzene on 50 g aluminum oxide (neutral, activity level 1)
8. customRecrystallization from methanol/water