HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 16-Azido-3-methoxyestra-1(10),2,4-trien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | HCID 21723401 | HCID 21723401 | — |
| Catalyst | chromium (VI) trioxide | HCID 10219390 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 16-Azido-3-methoxyestra-1(10),2,4-trien-17-one | HCID 162658 | — |
Reaction Steps
To a solution of 20 g 16α-azido-3-methoxy-estra-1,3,5(10)-triene-17β-ol in 11 acetone, 40 ml of 8 N chromium trioxide solution in conc. sulfuric acid is added dropwise at 0° C. and under stirring. After 2 h, 2 ml isopropanol are added and the reaction product is precipitated in crystalline form by dropwise addition of water. The product is filtered off, washed with water, dried and recrystallized from acetone/water. Yield: 16 g (81%), F=118-122° C.; [α]D+405°. IR: 1747 cm (CO), 2095 (N3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382288B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-47b6e540f34d4cbba60c0197cc9738c5 |
| Source note | uspto-grants-2016_07 |