Sodium Azide → HCID 11004210, compound

Participants

Reaction Steps

4 g (7.37 mmol) 3β-tosyloxy-5α-cholestane and 0.99 g (15.23 mmol) NaN3 are heated under stirring in 25 ml hexamethylphosphoric acid triamide (HMPT) for 3 h to 90° C. The reaction mixture is cooled and given into 100 ml ice water, the precipitated raw product subsequently removed by filtration, washed with water and dissolved in 60 ml ether. The organic phase is washed twice with water, dried over Na2SO4 and concentrated. The resulting wax-like product is directly processed further:

Provenance & Evidence