Propionyl chloride → Hydrochloric Acid

Participants

Reaction Steps

Compound 163 (50 mg, 0.085 mmol) was dissolved in 3 mL NMP. To it were added DIEA (74 μL, 0.425 mmol) and then propionyl chloride (23 mg, 0.255 mmol). The reaction was quenched in 10 m using TFA (0.2 mL). The mixture was directly subjected to reverse phase preparative HPLC to isolate (R)-5-(3-(4-methoxybenzamido)piperidin-1-yl)-3-(4-(1-propionylpiperidin-4-yl)phenylamino)pyrazine-2-carboxamide (170) as HCl salt. MS found for C32H39N7O4 as (M+H)+ 586.2, (M−H)− 584.4. UV: λ=257, 279, 304, 335, 372 nm.

Provenance & Evidence