Hydrochloric Acid → HCID 118115293, compound

Participants

Reaction Steps

(R)-tert-Butyl 3-(3-cyclopropyl-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate (391) (3.0 g, 9.7 mmol) was treated with commercial 4N HCl in dioxane at RT to afford (R)-1-cyclopropyl-3-(piperidin-3-yl)imidazolidin-2-one hydrochloride (392) (2.05 g, 86%) as a light brown solid after concentration in vacuo. Proton NMR (DMSO-d6): δ 9.37 (1H, s), 8.99 (1H, s), 3.89-3.82 (1H, m), 3.64-3.57 (1H, m), 3.28-3.18 (4H, m), 3.11-3.03 (1H, m), 2.97-2.87 (1H, m), 2.77-2.67 (1H, m), 2.44-2.29 (1H, m), 1.89-1.80 (1H, m), 1.75-1.64 (3H, m), 0.81-0.36 (4H, m) ppm.

Provenance & Evidence