4-Cyanophenylboronic acid → HCID 136413574, compound

HRID 1050765Notes

Reaction equation

HRID 1050765 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[C:15]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[N:14][S:13][C:9]2=[C:10](Br)[N:11]=1)=[O:5])[CH3:2].[C:24]([C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1)#[N:25]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[C:15]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[N:14][S:13][C:9]2=[C:10]([C:29]2[CH:30]=[CH:31][C:26]([C:24]#[N:25])=[CH:27][CH:28]=2)[N:11]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 136343982HCID 136343982, compound

Product 1

HCID 136413574HCID 136413574, compound

Procedure

The title compound was synthesized in analogy to Example 1 from 7-bromo-3-(4-fluoro-phenyl)-4-hydroxy-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester and 4-cyanophenylboronic acid: MS (m/z) 420.2 (M+1).

Sources & evidence

ORD record
ord-d23f1a4cc1b7430d82b7cdb6df12e56d
Source dataset
uspto-grants-2016_07
Patent number
US09387200B2

Reaction notes

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