Dimethyl acetylenedicarboxylate → Dimethyl 3-methyl-1,2-thiazole-4,5-dicarboxylate

Participants

Reaction Steps

A solution of 5-Methyl-[1,3,4]oxathiazol-2-one (37.94 mmol) and dimethylacetylenedicarboxylate (75.89 mmol) in chlorobenzene (22.3 mL) was refluxed with stirring for 6 h before the mixture was concentrated in vacuo. Distillation of the residue gave the desired product (4.38 g) at by 100-105° C. (1.0 Torr) as an oil: MS (m/z) 216.0 (M+1).

Provenance & Evidence