Glycine → HCID 135950375, compound

HRID 1050795Notes

Reaction equation

HRID 1050795 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:35])=[C:8]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[F:34])=[N:26][S:25][C:9]2=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:14][CH:13]=2)[N:11]=1)=[O:5])C.[NH2:36][CH2:37][C:38]([OH:40])=[O:39]>>[F:34][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[C:27]1[C:8]2[C:9](=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[CH:14][CH:13]=3)[N:11]=[C:6]([C:4]([NH:36][CH2:37][C:38]([OH:40])=[O:39])=[O:5])[C:7]=2[OH:35])[S:25][N:26]=1

Participants

3

Reactant 2

HCID 750GlycineHCID 136344027HCID 136344027, compound

Product 1

HCID 135950375HCID 135950375, compound

Procedure

The title compound was synthesized in analogy Example 1 from 3-(2-fluoro-phenyl)-4-hydroxy-7-(4-phenoxy-phenyl)-isothiazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester and glycine: MS (m/z) 516.1 (M+1).

Sources & evidence

ORD record
ord-a052bdb2592349fea2f5b092725749c9
Source dataset
uspto-grants-2016_07
Patent number
US09387200B2

Reaction notes

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